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Manju Ray Selected Research

Pyruvaldehyde (Methylglyoxal)

6/2019Methylglyoxal in combination with 5-Fluorouracil elicits improved chemosensitivity in breast cancer through apoptosis and cell cycle inhibition.
10/2018Methylglyoxal at metronomic doses sensitizes breast cancer cells to doxorubicin and cisplatin causing synergistic induction of programmed cell death and inhibition of stemness.
1/2017Induction of mitochondrial apoptotic pathway in triple negative breast carcinoma cells by methylglyoxal via generation of reactive oxygen species.
1/2016Creatine supplementation with methylglyoxal: a potent therapy for cancer in experimental models.
1/2015Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect.
1/2014Immunomodulation of macrophages by methylglyoxal conjugated with chitosan nanoparticles against Sarcoma-180 tumor in mice.
6/2012A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy.
6/2009Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in sarcoma-180 bearing mice: involvement of MAP kinase, NF-kappa beta signal transduction pathway.
11/2008Activation of macrophages and lymphocytes by methylglyoxal against tumor cells in the host.
1/2008A brief critical overview of the biological effects of methylglyoxal and further evaluation of a methylglyoxal-based anticancer formulation in treating cancer patients.
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Manju Ray Research Topics

Disease

15Neoplasms (Cancer)
02/2022 - 04/2006
7Carcinoma (Carcinomatosis)
06/2019 - 10/2002
7Ascites
06/2019 - 10/2002
5Sarcoma (Soft Tissue Sarcoma)
01/2016 - 06/2008
4Breast Neoplasms (Breast Cancer)
06/2019 - 01/2016
3Sarcoma 180
06/2012 - 06/2008
1Cachexia
01/2009
1Adenocarcinoma
06/2008
1Visceral Leishmaniasis (Kala Azar)
11/2007
1Infections
11/2007
1Hemolysis
11/2007
1Body Weight (Weight, Body)
04/2006

Drug/Important Bio-Agent (IBA)

12Pyruvaldehyde (Methylglyoxal)IBA
06/2019 - 06/2003
6CreatineIBA
01/2016 - 06/2003
4EnzymesIBA
02/2016 - 12/2008
4Creatine Kinase (Creatine Phosphokinase)IBA
06/2012 - 06/2008
3MethylcholanthreneIBA
02/2016 - 06/2008
3Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA
02/2016 - 02/2004
3Ascorbic Acid (Vitamin C)FDA LinkGeneric
01/2016 - 04/2006
2Adenosine Triphosphate (ATP)IBA
02/2022 - 01/2008
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2017 - 06/2009
2Proteins (Proteins, Gene)FDA Link
02/2016 - 01/2009
2CytokinesIBA
01/2014 - 11/2008
2glycine amidinotransferase (arginine-glycine amidinotransferase)IBA
06/2012 - 12/2008
2Guanidinoacetate N-Methyltransferase (Guanidinoacetate Methyltransferase)IBA
06/2012 - 12/2008
2Phosphocreatine (Neoton)IBA
06/2012 - 06/2008
2Messenger RNA (mRNA)IBA
01/2009 - 12/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2009 - 11/2008
1Pharmaceutical PreparationsIBA
02/2022
1Fluorouracil (Carac)FDA LinkGeneric
06/2019
1Cisplatin (Platino)FDA LinkGeneric
10/2018
1Doxorubicin (Adriamycin)FDA LinkGeneric
10/2018
1Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)IBA
02/2016
1Glucose (Dextrose)FDA LinkGeneric
02/2016
1Pyruvate KinaseIBA
02/2016
1ChitosanIBA
01/2014
1Immunologic Adjuvants (Immunologic Adjuvant)IBA
01/2014
1Macrophage Colony-Stimulating FactorIBA
01/2014
1Interleukin-6 (Interleukin 6)IBA
01/2014
1p38 Mitogen-Activated Protein KinasesIBA
06/2009
1NitrogenIBA
06/2009
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
01/2009
1CarcinogensIBA
01/2009
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
01/2009
1MyogeninIBA
01/2009
1Nitric Oxide Synthase (NO Synthase)IBA
01/2009
1Mitochondrial DNA (mtDNA)IBA
01/2009
1Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA
12/2008
1creatine transporterIBA
12/2008
1ArginaseIBA
12/2008
1CreatinineIBA
12/2008
1HomocysteineIBA
12/2008
1HydrolasesIBA
12/2008
1Methionine (L-Methionine)FDA Link
12/2008
1OrnithineIBA
12/2008
1glycocyamineIBA
12/2008
1PolyaminesIBA
12/2008
15-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)IBA
12/2008
1Oxygen (Dioxygen)IBA
11/2008
1Mitochondrial Form Creatine KinaseIBA
06/2008
1Indicators and Reagents (Reagents)IBA
06/2008
1Protein Isoforms (Isoforms)IBA
06/2008
1AntibodiesIBA
06/2008
1Biological ProductsIBA
01/2008
1Carrier Proteins (Binding Protein)IBA
11/2007
1QuercetinIBA
11/2007
1IronIBA
11/2007
1Serum AlbuminIBA
11/2007
1Hemoglobins (Hemoglobin)IBA
11/2007
1AlbuminsIBA
11/2007
1Histidine (L-Histidine)FDA Link
02/2004
1Glutathione (Reduced Glutathione)IBA
06/2003
1Phosphotransferases (Kinase)IBA
10/2002
13-phosphoglycerate (glycerate 3-phosphate)IBA
10/2002

Therapy/Procedure

3Therapeutics
01/2016 - 11/2007
2Immunomodulation
01/2014 - 06/2009